ZONISADE may cause serious skin reactions that can cause death. These serious skin reactions may include a severe rash with blisters and peeling skin, especially around the mouth, nose, eyes and genitals (Stevens-Johnson syndrome). ZONISADE may also cause a rash with blisters and peeling skin over much of the body (toxic epidermal necrolysis). Call your healthcare provider right away if you develop a skin rash.
ZONISADE can cause blood cell changes such as reduced red and white blood cell counts. Call your healthcare provider right away if you develop fever, sore throat, sores in your mouth, or easy bruising.
ZONISADE can cause other types of allergic reactions or serious problems that may affect different parts of the body such as your liver, kidneys, heart, or blood cells. You may or may not have a rash with these types of reactions. These reactions can be very serious and can cause death. Call your healthcare provider right away if you have:
- fever
- rash
- swelling of your face
- weakness, fatigue
- severe muscle pain
- swollen lymph glands
- unusual bruising or bleeding
- yellowing of your skin or the white part of your eyes
ZONISADE may cause decreased sweating and increased body temperature (fever). People, especially children, should be watched for signs of decreased sweating and fever, especially in hot temperatures. Some people may need to be hospitalized for this condition. If you have decreased sweating with or without a fever, call your healthcare provider right away.
ZONISADE may cause eye problems. Serious eye problems include:
- any sudden decrease in vision with or without eye pain and redness
- a blockage of fluid in the eye causing increased pressure in the eye (secondary angle closure glaucoma)
These eye problems can lead to permanent loss of vision if not treated.
Call your healthcare provider right away if you have any new eye symptoms, including any new problems with your vision.
Like other antiepileptic drugs, ZONISADE may cause suicidal thoughts. Call a healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:
- thoughts about suicide or dying
- new or worse depression
- feeling agitated or restless
- trouble sleeping (insomnia)
- acting aggressive, being angry, or violent
- an extreme increase in activity and talking (mania)
- attempt to commit suicide
- new or worse anxiety
- panic attacks
- new or worse irritability
- acting on dangerous impulses
- other unusual changes in behavior or mood
Suicidal thoughts or actions can be caused by things other than medicines. If you have suicidal thoughts or actions, your healthcare provider may check for other causes.
ZONISADE can cause abnormal heart rhythms, which may be life-threatening. This risk may be increased in patients with underlying heart problems. Call your healthcare provider right away if you have:
- A fast, slow or pounding heartbeat
- Loss of consciousness (fainting)
- Dizziness
- Chest pain
- Shortness of breath
ZONISADE can increase the level of acid in your blood (metabolic acidosis). If left untreated, metabolic acidosis can cause brittle or soft bones (osteoporosis, osteomalacia, osteopenia), kidney stones and can slow the rate of growth in children. Metabolic acidosis can happen with or without symptoms. Call your healthcare provider right away if you have any of these symptoms:
- fast breathing
- feel tired
- feel changes in heartbeat
- not feel hungry (loss of appetite)
- have trouble thinking clearly
Your healthcare provider should do a blood test to measure the level of acid in your blood before and during your treatment with ZONISADE.
ZONISADE may cause problems with thinking and alertness. ZONISADE may affect how you think and cause confusion, problems with concentration, attention, memory, or speech. ZONISADE may cause depression or psychotic symptoms (such as seeing or hearing things that are really not there), tiredness, and sleepiness.